砷中毒易感性与基因多态性的关系研究进展Recent Progress in Research on Susceptibility to Arsenic Poisoning and Genetic Polymorphism
邓芙蓉;郭新彪;
摘要(Abstract)：
无机砷是一种确认的人类致癌物,但其致癌机制至今仍不很清楚.人类的大多数肿瘤是环境与遗传因素共同作用的结果.砷中毒在不同种属(族)和个体之间存在着明显的差异,除年龄、性别、砷暴露量、营养状况等因素外,近年来研究发现,个体间砷中毒易感性的不同可能与某些基因多态性密切相关,这些基因包括谷胱苷肽-S-转移酶基因、5,10-亚甲基四氢叶酸还原酶基因、着色性干皮病D基因、髓性过氧化物酶基因、过氧化氢酶基因以及p53基因等.只有充分考虑遗传因素的作用,才能深入阐明砷中毒的机制.
关键词(KeyWords)： 砷;基因多态性;易感性
基金项目(Foundation): 国家自然科学基金项目(No.30170795)
作者(Author): 邓芙蓉;郭新彪;
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DOI:
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