徐红梅;宣怡红;江云;任娜;丁运生;吕丹;张毅帆;李小雪;周剑;许凯兵;

• 1:合肥工业大学医学工程学院 制药工程系
• 2:合肥工业大学安徽省先进功能材料与设备重点实验室
• 3:合肥工业大学化学工程学院

摘要(Abstract)：

研究离子液体溴化1-十四烷基-3-甲基咪唑盐([C14mim]Br)对小鼠的肝脏毒性及其作用机制。实验设立3个剂量的染毒组(1/16 LD50、1/8 LD50、1/4 LD50)和1个空白对照组,考察昆明种小鼠染毒14 d后,[C14mim]Br对小鼠血清生化指标、肝脏抗氧化酶活性及脂质过氧化产物的影响,并观察肝脏组织的病理变化。与对照组相比,小鼠染毒后,血清中ALT、AST、DBIL和γ-GT明显升高;肝组织受到不同程度的损伤,HSI增大,蛋白质含量降低。当染毒剂量为1/4 LD50时,肝脏中SOD活性和GSHPx活性显著降低,MDA的含量则明显增加。实验结果表明,[C14mim]Br可损伤小鼠的肝脏功能,破坏机体的抗氧化防御系统,造成氧化损伤和脂质过氧化。

关键词(KeyWords)： 离子液体;溴化1-十四烷基-3-甲基咪唑盐;肝毒性;小鼠

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(50973025);; 合肥工业大学大学生创新创业实验(2012CXCY475)

作者(Author): 徐红梅;宣怡红;江云;任娜;丁运生;吕丹;张毅帆;李小雪;周剑;许凯兵;

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DOI:

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