袁婷婷;王新亮;董慧峪;

• 1:北京医院检验科
• 2:天津市城市规划设计研究院
• 3:中国科学院生态环境研究中心

摘要(Abstract)：

卤代乙酰胺类(HAc Am)消毒副产物(DBPs)是饮用水中新兴含氮类DBPs之一。为探究HAc Ams的致突变性,选择小鼠淋巴瘤细胞作为受试细胞,分别考察了一氯代乙酰胺、二氯代乙酰胺、三氯代乙酰胺、一碘代乙酰胺、二碘代乙酰胺(DIAc Ams)共5种HAc Ams对小鼠淋巴瘤细胞Tk基因突变的影响。结果表明,在0.05~20μmol·L~(-1)暴露浓度下,5种HacAms类DBPs对小鼠淋巴瘤细胞呈现出一定的细胞毒性,随着暴露浓度的升高,细胞毒性增强。暴露4 h后,5种HacAms中只有DIAc-Ams呈现出显著的致突变性(暴露剂量高于5μmol·L~(-1)),且以小集落为主。上述研究结果为研究HacAms对哺乳动物细胞的致突变作用提供了基础数据。

关键词(KeyWords)： 卤代乙酰胺;小鼠淋巴瘤细胞;突变分析

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金课题(51408590)

作者(Author): 袁婷婷;王新亮;董慧峪;

Email:

DOI:

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