顾杰;吴江;王宏烨;石利利;吉贵祥;

• 1:生态环境部南京环境科学研究所
• 2:教育部现代毒理学重点实验室南京医科大学公共卫生学院

摘要(Abstract)：

国内外研究已证实,有机磷酸酯广泛分布于多种环境介质中,但目前仍缺乏足够的数据阐明有机磷酸酯具有早期神经毒性效应及其可能的毒性作用机制。本研究采用模式动物斑马鱼(Danio rerio)作为研究对象,选择了环境中3种典型的有机磷酸酯类化合物包括磷酸三苯酯(TPP)、2-乙基己基二苯基磷酸酯(EHDPP)和磷酸三(2-氯)乙酯(TCEP),从斑马鱼运动行为、氧化应激和神经发育关键基因的转录等方面阐述有机磷酸酯的早期神经毒性作用及可能的作用机制。研究发现,TPP(0.1和1 mg·L~(-1))、EHDPP(0.2和2 mg·L~(-1))和TCEP(0.5和5 mg·L~(-1))可能通过诱导氧化应激并下调神经发育关键基因(mbp和syn2a)的转录从而显著抑制斑马鱼的运动行为。本研究可以为有机磷酸酯类阻燃剂及其替代产品的生产、使用和危险度评估提供直接依据。

关键词(KeyWords)： 有机磷酸酯;斑马鱼;神经毒性

Abstract:

Keywords:

基金项目(Foundation): 现代毒理学教育部重点实验室(南京医科大学)开放项目(NMUMT201811)

作者(Author): 顾杰;吴江;王宏烨;石利利;吉贵祥;

Email:

DOI:

参考文献(References)：

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