微囊藻毒素神经毒理学研究进展Studies on Microcystin Neurotoxicology
居静娟;浦跃朴;尹立红;王大勇;
摘要(Abstract)：
微囊藻毒素(microcystins,MCs)是蓝藻产生的主要毒素,中毒人群或动物会表现出神经毒害症状,目前越来越多的研究关注其神经毒害及毒理。MCs可能由有机阴离子转运肽(OATP)转运并穿过血脑屏障,在动物脑组织中分布与蓄积。MCs会严重影响神经发育,损害动物的神经系统功能。MCs可能通过影响脑组织中的解毒与抗氧化系统,诱发其对动物神经系统发育与功能的伤害。在分析与讨论MCs神经毒理研究目前所面临的问题基础上,提出了相应研究策略的建议。
关键词(KeyWords)： 微囊藻毒素;神经毒理;模式动物
基金项目(Foundation): 国家自然科学基金项目(No.30870810,81072258,30901167,30972440);; 江苏省自然科学基金(No.BK2009281)
作者(Author): 居静娟;浦跃朴;尹立红;王大勇;
Email:
DOI:
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