张亚辉;曹莹;王一喆;刘征涛;

• 1:中国环境科学研究院环境基准与风险评估国家重点实验室

摘要(Abstract)：

氯酚类化合物是我国水体中广泛存在的一类优先控制污染物,以大型溞(Daphnia magna)为试验生物,测定了2,4-二氯酚、2,4,6-三氯酚和五氯酚对大型溞的48h致死的单一毒性和联合毒性。基于单一氯酚化合物的浓度-效应曲线,运用浓度加和(CA)与独立作用(IA)2个模型对2种等毒性浓度比的混合物(Mix-LC50和Mix-LC1)的联合毒性进行预测。通过氯酚混合物的观测数据的95%置信区间与CA和IA模型预测的浓度-效应曲线进行比较分析,结果表明,CA预测曲线与Mix-LC50和Mix-LC1这2种混合物的95%置信区间相近,而与IA的预测相差较大。以模型偏差率(MDR)表示CA或者IA预测效应浓度和观测值之间的偏差,在不同效应水平下CA对2种混合物的MDR值均小于1.5,说明CA能够预测3种氯酚化合物对大型溞的联合毒性。

关键词(KeyWords)： 联合毒性;氯酚;大型溞;浓度加和;独立作用

Abstract:

Keywords:

基金项目(Foundation): 国家水体污染控制与治理科技重大专项(2008ZX070526-003);; 环保公益性行业科研专项项目(201009026-04)

作者(Author): 张亚辉;曹莹;王一喆;刘征涛;

Email:

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