关于生态毒理学与环境毒理学几个基本概念的见解Discussion on Some Essential Concepts of Ecotoxicology and Environmental Toxicology
孟紫强;
摘要(Abstract)：
对生态毒理学和环境毒理学的几个基本概念进行了论述.首先,论述生态毒理学和环境毒理学的定义和各自的研究范畴,提出二者区分的条件和方法;其次,对“毒物”和“非毒物”的概念进行论述,否定了“物质即毒物”的论点;第三,论述“靶器官”概念的局限性及其对学科发展的不利影响,提出以“敏感器官”概念代替“靶器官”的见解.
关键词(KeyWords)： 生态毒理学;环境毒理学;毒物;非毒物;靶器官;敏感器官
基金项目(Foundation): 国家自然科学基金资助项目(No.30230310;No.20477023)
作者(Author): 孟紫强;
Email:
参考文献(References)：
- BallantyneB,MarrsT,SyversenT.1999.Generalandappliedtoxicology[M].2ndedition.Vol.1.NewYork:Grove’sDictionariesInc
- CalowP.1998.Handbookofecotoxicology[M].Oxford:BlackwellScienceLtd
- CockerhamLG,ShaneBS.1994.Basicenvironmentaltoxicology[M].BocaRatonFL:CRCPress
- ConnellDW,WuR,LamPetal.1999.Introductiontoecotoxicology[M].Cambridge:BlackwellScienceInc
- KlaassenCD.2001.CasarettandDoull’sToxicology:Thebasicscienceofpoisons[M].6thedition.NewYork:McGraw-HillPublishers
- LiSQ,1987.Healthtoxicology—principleandmethods[M].Chengdu:SichuanSciencePress(inChinese)
- LippmannM.2000.Environmentaltoxicology[M].NewYork:WileyJohnandSons
- LiuXL,LiH,MengZQ.2005a.OxidativedamageofPM2.5onhearts,lungsandtesticlesofrats[J].ChinEnvironSci,25(2):160-164(inChinese)
- LiuXL,MengZQ.2005b.Effectsofairbonefineparticlematteronantioxidantcapacityandlipidperoxidationinmultipleorgansofrats[J].InhalToxicol,17:467-473
- LiuXL,YangDS,MengZQ.2005c.Oxidationdamageofairbornefineparticlemattersonbrainsofrats[J].ChinJPublicHealth,21(8):990-991(inChinese)
- LiuYG,1997.Healthtoxicology[M].2ndedition.Beijing:People’sMedicalPublishingHouse(inChinese)
- LuFC.1996.Basictoxicology:fundamentals,targetorgans,and riskassessment[M].3rdediton.WashingtonDC:TaylorandFrancis
- MengZQ.1984.Kashin-BeckDisease[M].Taiyuan:ShanxiPeople’sPress(inChinese)
- MengZQ.2000.Environmentaltoxicology[M].Beijing:ChinaEnvironmentalSciencePress(inChinese)
- MengZQ.2001.Micronucleiinducedbyderivativesofsulfurdioxideinmousebanemarrowcellsinvivo[J].Toxicology,164:100
- MengZQ.2003a.Basicenvironmentaltoxicology[M].Beijing:AdvancedEducationPress(inChinese)
- MengZQ.2003b.Oxidativedamageofsulfurdioxideonvariousorgansofmice:sulfurdioxideisasystemicoxidativedamageagent[J].InhalToxicol,15:181-195
- MengZQ.2003c.OxidativestresseffectsofSO2anditssystemictoxin[J].ChinJPublicHealth,19(12):1422-1424(inChinese)
- MengZQ.2004.DNAdamagingeffectsofsulfurdioxidederivativesincellsfromvariousorgansofmice[J].Mutagenesis,119:465-468
- MengZQ,BaiJL,QinGH,etal.2005a.Alterationsofgenomeexpressionprofilesinratlungexposedtosulfurdioxide[J].JToxicology(Suppl.),19(3):228(inChinese)
- MengZQ,BaiW.2004.Oxidationdamageofsulfurdioxideontesticlesofmice[J].EnvironRes,96:298-304
- MengZQ,GengH,BaiJLetal.2003a.Bloodpressureofratsloweredbysulfurdioxideanditsderivatives[J].InhalToxicol,15:951-959
- MengZQ,HuM,GuoXB,etal.2003b.Studyingprogressoneffectsofsand-duststormsonhumanhealth[J].ChinJPublicHealth,19(4):471-472(inChinese)
- MengZQ,LiRJ,ZhangX.2005b.Levelsofsulfiteinthreeorgansfrommiceexposedtosulfurdioxide[J].InhalToxicol,17:309-313
- MengZQ,QinGH,ZhangB.2005c.DNAdamageinmicetreatedwithsulfurdioxidebyinhalation[J].EnvironMolMutagen,46:150-155
- MengZQ,SangN,ZhangB.2002a.Effectsofderivativesofsulfurdioxideonmicronucleiformationinmousebonemarrowcellsinvivo[J].BullEnvironContamToxicol,69:257-264
- MengZQ,ZhangB.2002b.Inductioneffectsofsulfurdioxideinhalationonchromosomalaberrationsinmousebonemarrowcells[J].Mutagenesis,17:215-217
- MengZQ,ZhangB.2003c.Oxidationdamageofsulfurdioxideinhalationonbrainsandliversofmice[J].EnvironToxicolPharmacol,13:1-8
- MengZQ,ZhangB,QinGH.2003d.Sulfurdioxideisasystemicoxidativedamageagent(Abstract)[J].Toxicology,191:28
- MengZQ,ZhangB,RuanADetal.2002c.Micronucleiinducedbysulfurdioxideinhalationinmousebone-marrowcellsinvivo[J].InhalToxicol,14:303-309
- MengZQ,ZhangLZ.1990.Chromosomalaberrationsandsister-chromatidexchangesoflymphocytesofworkersexposedtosulfurdioxide[J].MutatRes,24:15-20
- MengZQ,ZhangLZ.1992.Cytogeneticdamageinducedinhumanlymphocytesbysodiumbisulfite[J].MutatRes,298:63-69
- MichaelC,NewmanMC.2001.Populationecotoxicology[M].NewYork:WileyJohnandSons
- MoriartyF.1999.Ecotoxicology:Thestudyofpollutantsinecosystems[M].3rdedition.London:AcademicPress
- NewmanMC.1998.Fundamentalsofecotoxicology[M].BocaRatonFL:CRCPress
- NiimiAJ.1996.Environmentalcontaminationsinwildlife:Interpretingtissueconcentrations[M].BocaRatonFL:LewisPublishers,117
- RichardBP.2001.Ecosystemsandhumanhealth[M].BocaRatonFL:LewisPublishers
- SchüürmannG,MarkertB.1998.Ecotoxicology:Ecologicicalfundamentals,chemicalexposure,andbiologicaleffects[M].NewYork:WileyJohnandSons
- TimbrellJA.1995.Introductiontotoxicology[M].2ndediton.London:TaylorandFrancis
- WalkerCH.1999.Principlesofecotoxicology[M].2ndedition.London:TalorandFrancis
- WayneGL,MingHY.1995.Introductiontoenvironmentaltoxicology:Impactsofchemicaluponecologicalsystems[M].BocaRaton:CRCPress
- WienerJG,SpryDJ.1996.Environmentalcontaminantsinwildlife:Interpretingtissueconcentrations[M].BocaRatonFL:LewisPublishers,297-340
- ZhangX,LiuYG,1997.Toxicology[M].Beijing:UnitedPublishingHouseofBeijingMedicalUniversityandPekingUnionMedicalCollege(inChinese)
- ZhouQX,KongFX,ZhuL.2004.Ecotoxicology[M].Beijing:ChinaSciencePress(inChinese)
- 李寿祺主编.1987.卫生毒理学-基本原理和方法[M].成都:四川科学出版社
- 刘晓莉,李红,孟紫强.2005a.PM2.5对大鼠心、肺、睾丸的氧化损伤作用[J].中国环境科学,25(2):160-164
- 刘晓莉,杨东升,孟紫强.2005c.大气细颗粒物对大鼠脑组织的氧化损伤效应[J].中国公共卫生,21(8):990-991
- 刘毓谷主编.1997.卫生毒理学基础[M].第2版.北京:人民卫生出版社
- 孟紫强.1984.大骨节病[M].太原:山西人民出版社
- 孟紫强.2003c.氧化应激效应与SO2全身性毒作用研究[J].中国公共卫生,19(12):1422-1424
- 孟紫强主编.2000.环境毒理学[M].北京:中国环境科学出版社
- 孟紫强主编.2003a.环境毒理学基础[M].北京:高等教育出版社
- 孟紫强,白巨利,秦国华,等.2005a.二氧化硫吸入后大鼠肺组织基因表达谱的改变[J].毒理学杂志(增刊),19(3):228
- 孟紫强,胡敏,郭新彪,等.2003b.沙尘暴对人体健康影响的研究现状[J].中国公共卫生,19(4):471-472
- 张铣,刘毓谷主编.1997.毒理学[M].北京:北京医科大学、中国协和医科大学联合出版社
- 周启星,孔繁翔,朱琳主编.2004.生态毒理学[M].北京:科学出版社