汪正东;于云江;向明灯;李良忠;李辉;

• 1:华东理工大学资源与环境工程学院
• 2:环境保护部华南环境科学研究所

摘要(Abstract)：

为研究四溴双酚A(TBBPA)亚慢性呼吸暴露对大鼠的毒性效应,将36只健康的无特定病原菌级别(SPF级)Wistar雄性大鼠分为6组,分别为空白对照组、控制对照组和129、546、1 216、4 550μg·m-3TBBPA气溶胶染毒组,采用经口鼻呼吸暴露方式连续染毒90 d。暴露实验期间每天观察大鼠状态,每10天记录1次大鼠体重,于第91天解剖受试大鼠,分离主要脏器,并对肺组织进行病理检查。结果显示,与对照组比较,各暴露组大鼠肾脏及脾脏的脏器系数均有显著降低(P<0.05);TBBPA工业品气溶胶暴露组大鼠肺部病变程度和病变发生率高于空白对照组及控制对照组。研究结果表明Wistar大鼠经亚慢性呼吸暴露TBBPA颗粒后,可能造成一定程度的肾、脾脏毒性效应和肺部炎症。

关键词(KeyWords)： 四溴双酚A;TBBPA;雄性大鼠;呼吸暴露;亚慢性暴露;毒性效应;脏器系数

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(21177119;U1401233)

作者(Author): 汪正东;于云江;向明灯;李良忠;李辉;

Email:

DOI:

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