农药致慢性细胞毒性及基因毒性机制研究进展Progress in Mechanism of Pesticide-induced Cytotoxicity and Genotoxicity
陈洁;张积仁;
摘要(Abstract):
大量流行病学研究和体内、体外检测分析表明,长期低剂量接触农药可以导致人体细胞和分子损伤,诱导细胞凋亡。农药致细胞及DNA损伤的机制主要与DNA加合物的形成、DNA单链和/或双链的断裂有关。此外,氧化应激参与农药致细胞及DNA损伤的过程,可能成为农药致细胞及DNA损伤的促发因素。从总体上看,其具体分子机制还不十分清楚,有待进一步研究。
关键词(KeyWords): 农药;细胞毒性;基因毒性;氧化应激
基金项目(Foundation):
作者(Author): 陈洁;张积仁;
Email:
DOI:
参考文献(References):
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