溴阻燃剂对肝细胞的毒性Hepatotoxicity of Brominated Flame Retardants
那广水;孙丽娟;张雯雯;王惠国;
摘要(Abstract):
为评价四溴联苯醚(2,2,4,4-tetrabromodipheny lether,PBDE-47)、五溴联苯醚(2,2',4,4',5-pentabromodiphenylether,PBDE-99)、九溴联苯醚(polybrominated dipheny lethers206,PBDE-206)、六溴环十二烷(hexabromocyclododecane,HBCD)、四溴双酚A(tetrabromobisphenol A,TBBPA)对人肝细胞(LO2)的体外细胞毒性。将5种溴阻燃剂与人肝细胞LO2共同培养,采用四甲基偶氮噻唑蓝比色法(MTT法)检测5种溴阻燃剂对LO2细胞的相对增殖率,并按照GB/T16886.5-2003/ISO10993-5:1999标准评价5种溴阻燃剂对LO2的细胞毒性。体外实验表明,5种溴阻燃剂对LO2细胞均具有抑制作用,其中PBDE-47、PBDE-99和HBCD呈现剂量依赖关系。
关键词(KeyWords): 四溴联苯醚;五溴联苯醚;九溴联苯醚;六溴环十二烷;四溴双酚A;LO_2细胞
基金项目(Foundation): 海洋公益性科研专项(201105013)
作者(Author): 那广水;孙丽娟;张雯雯;王惠国;
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DOI:
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