纳米银的体内毒性及毒作用机制研究进展Research Progress on Internal Toxicity and the Toxic Mechanism of Silver Nanoparticles
王秀娟;薛玉英;唐萌;
摘要(Abstract):
很多研究表明纳米银对机体的消化系统、呼吸系统、生殖系统等多个系统均会产生毒作用,且其毒作用受到多种因素的影响。目前关于纳米银的毒作用机制尚未明确,研究发现纳米银的毒作用机制可能与银离子释放、活性氧自由基产生、氧化应激的发生、炎症反应等有关,最新研究指出纳米银的毒性作用还可能与内质网应激和自噬有关,本文将就纳米银的体内毒性及毒作用机制进行了综述。
关键词(KeyWords): 纳米银;活性氧;氧化应激;内质网应激;自噬
基金项目(Foundation): 国家自然科学基金项目(81573186,81473003)
作者(Author): 王秀娟;薛玉英;唐萌;
Email:
DOI:
参考文献(References):
- [1]邓芙蓉,魏红英,郭新彪.纳米银毒理学研究进展[J].环境工程技术学报,2011,1(5):420-424Deng F R,Wei H Y,Guo X B.Research progress in the toxicology of silver nanoparticles[J].Journal of Environmental Engineering Technology,2011,1(5):420-424(in Chinese)
- [2]Yun K,Oh G,Vang M,et al.Antibacterial effect of visible light reactive Ti O2/Ag nanocomposite thin film on the orthodontic appliances[J].Journal of Nanoscience and Nanotechnology,2011,11(8):7112-7114
- [3]Fondevila M,Herrer R,Casallas M C,et al.Silver nanoparticles as a potential antimicrobial additive for weaned pigs[J].Animal Feed Science and Technology,2009,150:259-269
- [4]Davenport L L,Hsieh H,Eppert B L,et al.Systemic and behavioral effects of intranasal administration of silver nanoparticles[J].Neurotoxicology and Teratology,2015,51:68-76
- [5]Van der Zande M,Vandebriel R J,Van Doren E,et al.Distribution,elimination,and toxicity of silver nanoparticles and silver ions in rats after 28-day oral exposure[J].ACS Nano,2012,6(8):7427-7442
- [6]Tak Y K,Pal S,Naoghare P K,et al.Shape-dependent skin penetration of silver nanoparticles:Does it really matter?[J].Scientific Reports,2015,5:16908-16918
- [7]Tang J,Xiong L,Wang S,et al.Influence of silver nanoparticles on neurons and blood-brain barrier via subcutaneous injection in rats[J].Applied Surface Science,2008,255(2):502-504
- [8]Florence A T.Nanoparticle uptake by the oral route:Fulfilling its potential?[J].Drug Discovery Today Technologies,2005,2(1):75-81
- [9]薛玉英,唐萌.纳米银生物学效应研究进展[J].东南大学学报:自然科学版,2009,39(6):1315-1320Xue Y Y,Tang M.Research progresses in biological effects of nanosilver[J].Journal of Southeast University:Natural Science Edition,2009,39(6):1315-1320(in Chinese)
- [10]Walczak A P,Fokkink R,Peters R,et al.Behaviour of silver nanoparticles and silver ions in an in vitro human gastrointestinal digestion model[J].Nanotoxicology,2013,7(7):1198-1210
- [11]Ebabe Elle R,Gaillet S,Vide J,et al.Dietary exposure to silver nanoparticles in Sprague-Dawley rats:Effects on oxidative stress and inflammation[J].Food and Chemical Toxicology,2013,7(60):297-301
- [12]Kim Y S,Song M Y,Park J D,et al.Subchronic oral toxicity of silver nanoparticles[J].Particle and Fibre Toxicology,2010,7:20-31
- [13]Qin G Q,Tang S,Li S B,et al.Toxicological evaluation of silver nanoparticles and silver nitrate in rats following28 days of repeated oral exposure[J].Environmental Toxicology,2017,32(2):609-618
- [14]Sung J H,Ji J H,Yoon J U,et al.Subchronic inhalation toxicity of silver nanoparticles[J].Inhalation Toxicology,2009,108(2):452-467
- [15]Hyun J S,Lee B S,Ryu H Y,et al.Effects of repeated silver nanoparticles exposure on the histological structure and mucins of nasal respiratory mucosa in rats[J].Toxicology Letters,2008,182(1/2/3):24-28
- [16]Silva R M,Anderson D S,Peake J,et al.Aerosolized silver nanoparticles in the rat lung and pulmonary responses over time[J].Toxicological Pathology,2016,44(5):673-686
- [17]Lee H Y,Choi Y J,Jung E J,et al.Genomics-based screening of differentially expressed genes in the brains of mice exposed to silver nanoparticles via inhalation[J].Journal of Nanoparticle Research,2010,12(5):1567-1578
- [18]Rahman M F,Wang J,Patterson T A,et al.Expression of genes related to oxidative stress in the mouse brain after exposure to silver-25 nanoparticles[J].Toxicology Letters,2009,187(1):15-21
- [19]Liu Y,Guan W,Ren G,et al.The possible mechanism of silver nanoparticle impact on hippocampal synaptic plasticity and spatial cognition is rats[J].Toxicology Letters,2012,209(3):227-231
- [20]徐丽明,陈亮,董喆,等.纳米银凝胶在家兔体内的生殖器官毒性及体外细胞毒性研究[J].药物分析杂志,2012(2):194-201Xu L M,Chen L,Dong Z,et al.In vivo toxicity and in vitro cytotoxicity of silver nanoparticle based-hydrogel in reproductive organs of rabbit and Hela sells[J].Chinese Journal of Pharmaceutical Analysis,2012(2):194-201(in Chinese)
- [21]Melnik E A,Buzulukov Y P,Demin V F,et al.A transfer of silver nanoparticles through the placenta and breast during in vivo experiments on rats[J].Acta Nature,2013,5(3):107-115
- [22]Charehsaz M,Hougaard K S,Sipahi H,et al.Effects of developmental exposure to silver in ionic and nanoparticle form:A study in rats[J].DARU Journal of Pharmaceutical Sciences,2016,24(1):1-13
- [23]Ema M,Okuda H,Gamo M,et al.A review of reproductive and developmental toxicity of silver nanoparticles in laboratory animals[J].Reproductive Toxicology,2017,67:149-164
- [24]Kim J S,Song K S,Sung J H,et al.Genotoxicity,acute oral and dermal toxicity,eye and dermal irritation and corrosion and skin sensitisation evaluation of silver nanoparticles[J].Nanotoxicology,2013,7(5):953-960
- [25]Samberg M E,Oldenburg S J,Monteiroriviere N A.Evaluation of silver nanoparticle toxicity in skin in vivo and keratinocytes in vitro[J].Environmental Health Perspectives,2010,118(3):407-413
- [26]Recordati C,Maglie M D,Bianchessi S,et al.Tissue distribution and acute toxicity of silver after single intravenous administration in mice:Nano-specific and size-dependent effect[J].Particle and Fibre Toxicology,2016,13(12):1-17
- [27]Kwok K W,Dong W,Marinakos S M,et al.Silver nanoparticle toxicity is related to coating materials and disruption of sodium concentration regulation[J].Nanotoxicology,2016,10(9):1306-1317
- [28]Long Y M,Zhao X C,Clermont A C,et al.Negatively charged silver nanoparticles cause retinal vascular permeability by activating plasma contact system and disrupting adherens junction[J].Nanotoxicology,2016,10(4):501-511
- [29]Hadrup N,Lam H R.Oral toxicity of silver ions,silver nanoparticles and colloidal silver-A review[J].Regulatory Toxicology and Pharmacology,2014,68:1-7
- [30]Matteis V D,Malvindi M A,Galeone A,et al.Negligible particle-specific toxicity mechanism of silver nanoparticles:The role of Ag+ion release in the cytosol[J].Nanomedicine:Nanotechnology,Biology,and Medicine,2015,11(3):731-739
- [31]Xu L,Xu Q H,Zhou X Y,et al.Mechanisms of silver nanoparticles induced hypopigmentation in embryonic zebrafish[J].Aquatic Toxicology,2017,184:49-60
- [32]Chen Y K,Zheng X B,Xie Y T,et al.Silver release from silver-containing hydroxyapatite coatings[J].Surface&Coatings Technology,2010,205(7):1892-1896
- [33]Mc Shan D,Ray P C,Yu H T.Molecular toxicity mechanism of nanosilver[J].Journal of Food and Drug Analysis,2014,22(1):116-127
- [34]Fu P P,Xia Q S,Hwang H M,et al.Mechanisms of nanotoxicity:Generation of reactive oxygen species[J].Journal of Food and Drug Analysis,2014,22(1):64-75
- [35]Asharani P V,Mun G L K,Hande M P,et al.Cytotoxicity and genotoxicity of silver nanoparticles in human cells[J].ACS Nano,2009,3(2):279-290
- [36]Gaillet S,Rouanet J M.Silver nanoparticles:Their potential toxic effects after oral exposure and underlying mechanisms-A review[J].Food and Chemical Toxicology,2015,77:58-63
- [37]Braakhuis H M,Cassee F R,Fokkens P H,et al.Identification of the appropriate dose metric for pulmonary inflammation of silver nanoparticles in an inhalation toxicity study[J].Nanotoxicicology,2016,10(1):63-73
- [38]Bermejo-Nogales A,Fernandez M,Fernandez-Cruz M L,et al.Effects of a silver nanomaterial on cellular organelles and time course of oxidative stress in a fish cell line(PLHC-1)[J].Comparative Biochemistry and Physiology,Part C,2016,190:54-65
- [39]Xiao H B,Liu X,Wu C,et al.A new endoplasmic reticulum-targeted two-photon fluorescent probe for imaging of superoxide anion in diabetic mice[J].Biosensors&Bioelectronics,2017,91:449-455
- [40]Huo L,Chen R,Zhao L,et al.Silver nanoparticles activate endoplasmicreticulum stress signaling pathway in cell and mouse models:The role in toxicity evaluation[J].Biomaterials,2015,61:307-315
- [41]Christen V,Capelle M,Fent K.Silver nanoparticles induce endoplasmatic reticulum stress response in zebrafish[J].Toxicology and Applied Pharmacology,2013,272(2):519-528
- [42]Chen R,Zhao L,Bai R,et al.Silver nanoparticles induced oxidative and endoplasmic reticulum stresses in mouse tissues:Implications for the development of acute toxicity after intravenous administration[J].Toxicology Research,2016,5:602-609
- [43]Zhang J Q,Zhou W,Zhu S S,et al.Persistency of enlarged autolysosomes underscores nanoparticle-induced autophagy in hepatocytes[J].Small,2017,13(7),DOI 10.1002/smll.201602876.
- [44]Jeong J K,Gurunathan S,Kang M H,et al.Hypoxia-mediated autophagic flux inhibits silver nanoparticle triggered apoptosis in human lung cancer cells[J].Scientific Reports,2016,6:21688
- [45]朱琪,林芳.自噬的分子标志物[J].药学学报,2016(1):33-38Zhu Q,Lin F.Molecular markers of autophagy[J].Acta Pharmaceutica Sinica,2016(1):33-38(in Chinese)
- [46]Mao B H,Tsai J C,Chen C W,et al.Mechanisms of silver nanoparticle-induced toxicity and important role of autophagy[J].Nanotoxicity,2016,10(8):1021-1040
- [47]Lee T Y,Liu M S,Huang L J,et al.Bioenergetic failure correlates with autophagy and apoptosis in rat liver following silver nanoparticle intraperitoneal administration[J].Particle and Fibre Toxicology,2013,10(40):1-13
- [48]Mishra A R,Zheng J,Tang X,et al.Silver nanoparticleinduced autophagic-lysosomal disruption and NLRP3-inflammasome activation in Hep G2 cells is size-dependent[J].Toxicological Sciences,2016,150(2):473-487
- [49]Miyayama T,Matsuoka M.Involvement of lysosomal dysfunction in silver nanoparticle-induced cellular damage in A549 human lung alveolar epithelial cells[J].Journal of Occupational Medicine and Toxicology,2016,11(1):1-6
- [50]Lee Y H,Cheng F Y,Chiu H W,et al.Cytotoxicity,oxidative stress,apoptosis and the autophagic effects of silver nanoparticles in mouse embryonic fibroblasts[J].Biomaterials,2014,35(16):4706-4715