铅(Pb~(2+))致高血压大鼠胸主动脉病变的相关基因及信号转导途径The Related Genes and Possible Signal Transduction Paths in the Pathological Changes of the Thoracic Aortae of the Hypertensive Rats Induced by Exposure to Lead(Pb~(2+))
张乐丰;王生;彭双清;董延生;韩刚;
摘要(Abstract):
采用表达芯片研究铅(Pb2+)致高血压大鼠模型病变主动脉的基因表达谱,以及可能涉及的信号转导途径.结果表明,Pb2+致高血压大鼠和对照组相比,在3463个已知基因和表达序列标签(EST)中,有24个基因和1个EST表达上调幅度≥2倍;有2个基因和1个EST表达下调幅度≥2倍.在差异表达≥2倍的26个基因中,有13个上调的基因与细胞凋亡、局部粘附、细胞生长、增殖、细胞迁移、平滑肌兴奋、胶原重构等生物学过程相关;2个下调基因与能量代谢有关.表达差异基因相对集中的信号途径是与细胞运动、增殖和存活关系密切的局部粘附信号途径.
关键词(KeyWords): 高血压;基因芯片;铅(Pb~(2+));大鼠
基金项目(Foundation): 国家自然科学基金项目(No.39400113);; 军事医学科学院创新基金项目(No.2003A)
作者(Author): 张乐丰;王生;彭双清;董延生;韩刚;
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