金小伟;王子健;王业耀;刘娜;

• 1:中国环境监测总站
• 2:中国科学院生态环境研究中心
• 3:中国地质大学(北京)

摘要(Abstract)：

繁殖/生殖毒性类化合物由于特殊的毒理作用模式(mode of action,MOA),通过影响生物繁衍影响到种群和群落,因此依靠基于急、慢性毒性测试终点和传统基准推导方法推导的水生态基准值并不能够为水生生物群落结构提供足够的保护。本文根据文献资料,分析了推导此类化合物水生态基准时的关键科学问题,包括繁殖/生殖毒性类化合物MOA,毒性数据类型,受试物种选择,以及不同生命阶段、多代毒性测试和测试终点的判别和选择。并用所收集的壬基酚数据,尝试推导了基于水生生物生殖毒性的水生态基准值。研究得出基于生殖毒性的壬基酚预测无观察效应浓度(PNEC)值为0.12μg·L-1,其数值比美国环境保护局根据传统基准方法推导的基准持续浓度(CCC)的6.59μg·L-1低了近50倍。因此,基于其繁殖毒性(包括产卵量、受精率、孵化率、多代效应以及种群变化等)的实验结果更适合用于具有繁殖/生殖毒性污染物水生态基准的推导。

关键词(KeyWords)： 壬基酚;内分泌干扰物;淡水生物;繁殖/生殖毒性;水质基准

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学青年基金(21307165);; 环境模拟与污染控制国家重点联合实验室(中国科学院生态环境研究中心)开放基金(14K02ESPCR)

作者(Authors): 金小伟;王子健;王业耀;刘娜;

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